Well-dispersed core-shell SiO2-PMMA nanoparticles were prepared by using MPS as bridge in aqueous solution. In addition, NR latex was modified by PMMA in emulsion system before mixing with core-shell nanoparticles via combining similar dissolve mutually theory and latex-compounding techniques. It is proved that this method is useful and core-shell SiO2-PMMA nanoparticles are rarely reported in NR latex application, and we will systematically discuss the synthesizing process and also investigate the relationship between microstructure and macroproperties.