Non-conventional yeasts can provide many potential advantages over S. cerevisiae with respect to pathway requirements, desired product profile, and gross physiology (Gellissen and Hollenberg, 1997; Wolf, 2012).
While some non-conventional yeasts have served as long-standing industrial protein production platforms, their utility in the small molecule chemical space is sometimes limited to native metabolite overproduction phenotypes.
However, the increasing availability of high-quality yeast
genome sequences