zinc sulfate-treated mice showed no avoidance behavior for acetic
acid (data not shown). These results suggest that zinc sulfate
treatment severely damaged mouse olfaction. The inhalation of
diacetone alcohol (0.1mg/cage) in the mice with impaired olfactory
epithelium did not reduce locomotor activity (Fig. 5), suggesting
that a pathway through the olfactory epithelium played an
important role in the sedative activities of inhaled diacetone
alcohol.