Fig. 2.Effect of MLPII on insulin secretion and pancreatic islet cell apoptosis in diabetic rats. A, the serum and pancreas insulin levels in normal control group (NC), untreated diabetic group
(UD) and MLPII-treated diabetic group (MD) were determined by radioimmunoassay. B, insulin-positive cells were detected by immunohistochemical analysis in (a) normal control
group, (b) untreated diabetic group and (c) MLPII-treated diabetic group (Bar = 20μm). Ultrastructural changes of pancreaticβ-cells were observed in (d) normal control group,
(e) untreated diabetic group and (f) MLPII-treated diabetic group. n: Nucleus, m: Mitochondria, secretory granules (arrows) (Bar = 2μm). Pancreatic islet apoptosis was examined by
TUNEL assay in (g) normal control group, (h) untreated diabetic group and (i) MLPII-treated diabetic group (Bar = 20μm). C, The apoptotic index was measured in the pancreatic islets
of normal control group (NC), untreated diabetic group (UD) and MLPII-treated diabetic group (MD).