Medical therapy has been largely di

Medical therapy has been largely disappointing and inadequate. Many newborn infants with progressive cranial enlargement secondary to intracranial hemorrhage demonstrate spontaneous stabilization and resolution. Serial lumbar punctures and medications have been used with varying success but are recommended only until the preterm infant is stable enough to tolerate major surgery. The administration of acetazolamide and isosorbide or furosemide is somewhat beneficial in decreasing the production of CSF in selected cases of slowly progressive disease. The medication reduces the ICP until spontaneous arrest of hydrocephalus takes place or as a temporary measure when surgery is contraindicated.