Elderly: More elderly patients are being treated with
statins. As muscle mass decreases with aging, there
may be an increased risk of my opathy in elderly patients.
In addition, polypharmacy is pervasive in the elderly and
increases the chance of a DDI. As age increases, metabolizing
enzymes may be less functional as well, increasing the likelihood
of increased AUC and more DDIs. It is critical that elderly
patients on polypharmacy be regularly reevaluated for the risk
of DDIs and drug lists be rigorously kept up to date.33-36
Atorvastatin and rosuvastatin may mildly increase serum
Concentrations of ethinyl estradiol and norgestrel, which may
be used as part of postmenopausal therapies.