which had a parent-of-origin-specif

which had a parent-of-origin-specific effect [23], in addition to 15 variants that were significant genome-wide in Asian populations only. The top-ranked SNP at DUSP9 on the X chromosome was also unavailable and without a suitable proxy, and was therefore not included. Hence, a total of 49 variants were selected for the InterAct genetic score, including two established obesity loci (FTO and MC4R) and two loci that reached genome-wide significance in sex-differentiated meta-analyses (CCND2 and GIPR) [22]. The top-ranked SNP at HNF1B (rs11651052) was not available on the Illumina 660 W-Quad BeadChip, and a proxy in high linkage disequilibrium (rs4430796; r2 = 0.97) was used instead. Risk alleles (Table S4) were summed into a genetic risk score, including imputation of missing genotypes.