Conclusion
Although andrographolide keeps the potency of a suitable
lead candidate against malaria, further optimizations are
needed for its inclusion in the future prophylaxis as a
therapeutic agent. Relatively rapid development of resistance
to most of the drugs arises in response to drug pressure
[26]. It can also happen in the recent future to the ACT,
which is now being promoted as a gold standard for malaria
therapy by World Health Organization. The synergistic
activity of andrographolide with curcumin could address
this issue and generate optimism for further exploration of
a new anti-malarial formula by modifying the molecular
structures in various possible ways. Of course, equally
important will be the investigative line which would study
the bioavailability of the said compounds in in vivo system.