moreover,clearance decreased from 3.43 L/hour (10th and 90th percentile of 2.12 and 5.17, respectively)in patients with normol renal function to 2.65 L/hour (10th and 90th percentile of 1.73 and 4.02,respectively) and to 2.07 L/hour (10th and 90th percentile of 1.15 and 2.73, respectively) in patients with moderate IRF.