The current crop of antibiotics in

The current crop of antibiotics in clinical use are either natural products or their derivatives. However, the
rise of a multitude of different antibiotic resistant human pathogens has meant that new antibiotics are
urgently needed. Unfortunately, the search for new antibiotics from traditional bacterial sources often
results in a high rediscovery rate of known compounds and a low chance of identifying truly novel chemical
entities. To overcome this, previously unexplored (or under investigated) bacterial sources are being
tapped for their potential to produce novel compounds with new activities. Here, we review a number of
antibiotic compounds identified from bacteria of the genera Burkholderia, Clostridium, Lysobacter, Pantoea
and Xenorhabdus and describe the potential of organisms and their associated metabolites in future drug
discovery efforts.