handsearched relevant conference proceedings, and contacted experts in the area and manufacturers of enteral and parenteral nutrition
products. We did not limit the search by language or publication status.
Selection criteria
We included studies if they were randomized controlled trials; involved paediatric patients, aged one day to 18 years of age, who were
cared for in a paediatric intensive care unit setting (PICU) and had received nutrition within the first seven days of admission; and
reported data for at least one of the pre-specified outcomes (30-day or PICU mortality; length of stay in PICU or hospital; number
of ventilator days; and morbid complications, such as nosocomial infections). We excluded studies if they only reported nutritional
outcomes, quality of life assessments, or economic implications. Furthermore, we did not address other areas of paediatric nutrition,
such as immunonutrition and different routes of delivering enteral nutrition, in this review.