1. Introduction
The discoveries leading to information on novel drugs and
drug combinations have become a priority to manage the
increasing burden of malaria, caused by drug resistant
parasites. Artemisinin derivative-based drug combinations
that have independent mode of action are seen as a way of
enhancing efficacy and simultaneously ensuring protection
against resistance [1, 2] among the parasites. The antimalarial
properties of a tropical plant Andrographis paniculata
has been studied in details recently by Mishra et al.
[3], and also, there are several reports that demonstrate
the antimalarial properties of the plant A. paniculata [4–
6], but there is hardly any report that describe the active
compound responsible for the anti-malarial property of this
plant. Andrographolide, the diterpenic lactone compound, is
one of themajor phytoconstituents of the plant A. paniculata
and has been reported to have diverse pharmacological
potential including antiviral [7], anti-inflammatory [8–11],
no. 3731-100MG) and curcumin (98% Curcuminoid content,
Sigma, USA; Cat no. 7727) were purchased commercially.