Plaunotol, [(2E,6Z,10E)-7-hydroxyme

Plaunotol, [(2E,6Z,10E)-7-hydroxymethyl-3,11,15-trime- thyl-2,6,10,14-hexadecatetraen-1-ol], is an acyclic diterpene alcohol extracted from a Thai medicinal plant, plau-noi, and is widely used in the treatment of peptic ulcers in Japan. As a gastroprotective agent, plaunotol has excellent anti-ulcer activity both in experimental ulcers and in clinical trials (Karita et al., 1995; Kohda et al., 1991). It is also used in combination therapies against Helicobacter pylori-associated diseases because of its strong bactericidal effect against H. pylori (Karita et al., 1993; Koga et al., 1996; Shirai et al., 1995)