As such, induction of proteotoxic s

As such, induction of proteotoxic stress—by inhibiting the activity of UPS—has been addressed as an effective therapeutic strategy for hematologic malignancies and multiple myeloma (Deshaies 2014). Recently, targeting UPS in the treatment ofsolid malignancies were demonstrated (Nawrocki et al. 2002; Calvaruso et al. 2006; Vaeteewoottacharn et al. 2013).