Risk factors for HFMD and herpangina included playing with neighborhood children (odds ratio [OR]: 11 [95% confidence interval (CI): 6.2–17]), visiting an outpatient clinic for another reason ≤ 1 week before onset (OR: 20 [95% CI: 5.0–88]), and community exposures to crowded places (OR: 7.3 [95% CI: 4.1–13]). By using a score summarizing responses to 4 hand-washing questions, we found that 50% of the case-children and 2.5% of control-children had a poor score of 1 to 3, whereas 12% of the case-children and 78% of control-children had a good score of ≥7 (OR: 0.00069 [95% CI: 0.0022–0.022]) after we adjusted for residency, age, and community exposures by using logistic regression.