3.2. FIA titration in non-aqueous medium
Because of the above-described problems in analysis of
medicinal forms in coated tables by the FIA titration method
in aqueous micellar medium, a flow-through variant of the official
method of determination of phenothiazine derivatives
by potentiometric titration with perchloric acid in acetic acid
medium was developed. FIA titration in the high-speed arrangement
was selected, as because of the corrosive reaction
medium, it would be necessary to make the mixing gradient
chamber from resistant teflon. Also, the maximum sampling
frequency is higher in high-speed arrangement. The potentiometric
detection is suitable for the determination of samples
with higher concentrations of the substances than the spectrophotometric
one.