Probiotics reshaped the gut microbiota composition and increased intestinal bacterial diversity. The lipid-lowering efficacy of may probiotics be attributed to the increase in the relative abundance of anti-obesity-related bacteria and a reduction in obesity-associated bacterial genera. the enrichment of key metabolites and their corresponding metabolic pathways after supplementation with probiotics may lower lipid levels in patients with fatty liver disease. The lipid-lowering effect of probiotics and provide a foundation for investigating the mechanism of lipid reduction in individuals with fatty liver disease.