Increasedconcernforthewelfareofpedi

Increasedconcernforthewelfareofpedigreedogshasledtodevelopmentofselectionprogramsagainstinheriteddiseases.Anexampleiscaninehipdysplasia (เด็ฏ), whichhasamoderateheritabilityandahighprevalenceinsomelarge-sizedbreeds Todate, selectionusingphenotypeshasledtoonlymodestimprovement, mayprovemoreeffective andalternativestrategiessuchasgenomicselection (GS) Theprimaryaimsofthisstudyweretocomparetheperformanceofpedigree-andgenomic-basedbreedingagainstCHDintheUKLabradorretrieverpopulationandtoevaluatetheperformanceofdifferentGSmethods.Asampleof1179LabradorRetrieversevaluatedforCHDaccordingtotheUKscoringmethod (hipscore, HS) wasgenotypedwiththeIlluminaCanineHDBeadChip.TwelvefunctionsofHSanditscomponenttraitswereanalyzedusingdifferentstatisticalmethods (GBLUP, BayesCandSingle-Stepmethods) usingcross andresultswerecomparedwithapedigree-basedapproach (BLUP) -ตรวจสอบ Genomicmethodsresultedinsimilarorhigheraccuraciesthanpedigree-basedmethodswithtrainingsetsof944individualsforallbuttheuntransformedHS,suggestingthatGSisaneffectivestrategy.GBLUPandBayesCgavesimilarpredictionaccuraciesforHSandrelatedtraits, indicatingapolygenicarchitecture ข้อสรุปนี้ยังได้รับการสนับสนุน โดย lowaccuraciesobtainedinadditionalGBLUPanalysesperformedusingonlytheSNPswithhighestteststatistics, alsoindicatingthatmarker-assistedselection (มาส) wouldnotbeaseffectiveasGS.ASingle-StepmethodthatcombinesgenomicandpedigreeinformationalsoshowedhigheraccuracythanGBLUPandBayesCforthelog-transformedHS,whichiscurrentlyusedforpedigreebasedevaluationsinUK.Inconclusion,GSisapromisingalternativetopedigree-basedselectionagainstCHD, requiringmorephenotypeswithgenomicdatatoimprovefurthertheaccuracyofprediction

Increasedconcernforthewelfareofpedigreedogshasledtodevelopmentofselectionprogramsagainstinheriteddiseases.Anexampleiscaninehipdysplasia(CHD),whichhasamoderateheritabilityandahighprevalenceinsomelarge-sizedbreeds.Todate,selectionusingphenotypeshasledtoonlymodestimprovement,andalternativestrategiessuchasgenomicselection(GS)mayprovemoreeffective.Theprimaryaimsofthisstudyweretocomparetheperformanceofpedigree-andgenomic-basedbreedingagainstCHDintheUKLabradorretrieverpopulationandtoevaluatetheperformanceofdifferentGSmethods.Asampleof1179LabradorRetrieversevaluatedforCHDaccordingtotheUKscoringmethod(hipscore,HS)wasgenotypedwiththeIlluminaCanineHDBeadChip.TwelvefunctionsofHSanditscomponenttraitswereanalyzedusingdifferentstatisticalmethods(GBLUP,BayesCandSingle-Stepmethods),andresultswerecomparedwithapedigree-basedapproach(BLUP)usingcross-validation.Genomicmethodsresultedinsimilarorhigheraccuraciesthanpedigree-basedmethodswithtrainingsetsof944individualsforallbuttheuntransformedHS,suggestingthatGSisaneffectivestrategy.GBLUPandBayesCgavesimilarpredictionaccuraciesforHSandrelatedtraits,indicatingapolygenicarchitecture.This ข้อสรุปที่ได้รับการสนับสนุนด้วยโดย lowaccuraciesobtainedinadditionalGBLUPanalysesperformedusingonlytheSNPswithhighestteststatistics,alsoindicatingthatmarker-assistedselection(MAS)wouldnotbeaseffectiveasGS.ASingle-StepmethodthatcombinesgenomicandpedigreeinformationalsoshowedhigheraccuracythanGBLUPandBayesCforthelog-transformedHS,whichiscurrentlyusedforpedigreebasedevaluationsinUK.Inconclusion,GSisapromisingalternativetopedigree-basedselectionagainstCHD,requiringmorephenotypeswithgenomicdatatoimprovefurthertheaccuracyofprediction.

increasedconcernforthewelfareofpedigreedogshasledtodevelopmentofselectionprogramsagainstinheriteddiseases . anexampleiscaninehipdysplasia ( CHD ) whichhasamoderateheritabilityandahighprevalenceinsomelarge sizedbreeds . ถึงวันที่ selectionusingphenotypeshasledtoonlymodestimprovement andalternativestrategiessuchasgenomicselection , , ( GS ) mayprovemoreeffective .theprimaryaimsofthisstudyweretocomparetheperformanceofpedigree andgenomic basedbreedingagainstchdintheuklabradorretrieverpopulationandtoevaluatetheperformanceofdifferentgsmethods . asampleof1179labradorretrieversevaluatedforchdaccordingtotheukscoringmethod ( hipscore HS ) wasgenotypedwiththeilluminacaninehdbeadchip .twelvefunctionsofhsanditscomponenttraitswereanalyzedusingdifferentstatisticalmethods ( gblup bayescandsingle , stepmethods ) andresultswerecomparedwithapedigree basedapproach ( blup ) usingcross การตรวจสอบ genomicmethodsresultedinsimilarorhigheraccuraciesthanpedigree-basedmethodswithtrainingsetsof944individualsforallbuttheuntransformedhs suggestingthatgsisaneffectivestrategy , .gblupandbayescgavesimilarpredictionaccuraciesforhsandrelatedtraits indicatingapolygenicarchitecture.this สรุป , ได้รับการสนับสนุนโดย lowaccuraciesobtainedinadditionalgblupanalysesperformedusingonlythesnpswithhighestteststatistics alsoindicatingthatmarker assistedselection , ( แต่ ) wouldnotbeaseffectiveasgs .ซิงเกิ้ล stepmethodthatcombinesgenomicandpedigreeinformationalsoshowedhigheraccuracythangblupandbayescforthelog transformedhs whichiscurrentlyusedforpedigreebasedevaluationsinuk , . ได้ gsisapromisingalternativetopedigree basedselectionagainstchd requiringmorephenotypeswithgenomicdatatoimprovefurthertheaccuracyofprediction , .