Discussion Melasma is a common hype

Discussion
Melasma is a common hyperpigmentation disorder that typically affects women. However, in one study it has been reported that up to 10% of white individuals seeking treatment for melasma are men.24but in our study majority are males (86.6%) were participated in our study.
Weobserved mainly in the age group of 25- 50 years (80%) this is supported by Griffiths CEM et al., showed on average of 30years at onset.25
There are several theories describing the etiology of melasma in men. Chronic sun exposure seems to be the most likely cause in most cases or at least the most important exacerbating factor.Mostly all our patients had a history of sun-exposure. That out of 15 patients 12(80%) patients had a history of sun exposure similarly it was supported byVazquez et al reported81.4% (22/27) of patients had a history of chronic sun exposure and 66.6% (18/27) noticed worsening of their condition with sunlight exposure.26 Griffiths CEM et al showed that sunlight was an exacerbating factor in 98% patients.25
In our study 4 (26.6%) patients had family history of melasma this is supported by Vazquez et al reported that 70.4% (19/27) of men in their study had a family history of melasma in first- or second-degree relatives, though none of the men reported melasma in their fathers.26 Griffiths CEM et al 47% patients gave a positive family history of first degree of relative being affected.25
Drug in take had no significant association with occurrence of melasma in our patients. And no patient had a history of thyroid disorder.
Ours is a pilot study, aimed to know the effect of glutathione in soap form. Though all most all the patients had decreased effect of hyperpigmentation, it is supported byNutthavutharjinpathana et al at 4 weeks, the melanin indices decreased consistently at all six sites in subjects who received glutathione orally