Primary site of tumor39
– Posterior mandible is more commonly affected by ORN because of its
compact and dense nature
Proximity of tumor to bone4
Extent of mandible included in primary radiation field23
State of dentition – odontogenic and periodontal disease40
Poor oral hygiene40
Radiation dose >60 Gy23
Use of brachytherapy4,23
Nutritional status4
Concomitant chemo-radiation
Ill-fitting tissue borne prosthesis resulting in chronic trauma39
Acute trauma from surgical procedures to the jaw23
Advanced stage tumors38,39,41