The mean (SD) T-SPOT.TB ESAT-6 resp

The mean (SD) T-SPOT.TB ESAT-6 response was higher than
the CFP-10 response in all participants (111.7 (134.5) vs 26.6
(44.4); Wilcoxon sign test, p(0.001). In contrast, the mean
(SD) QTF CFP-10 response was higher than the mean ESAT-6
response in all participants (5.1 (10.0) vs 1.5 (3.5); Wilcoxon sign
test, p(0.001). There was a significant difference in the
magnitude of the T-SPOT.TB ESAT-6 and CFP-10 spot counts
between adults and children (mean (SD) ESAT-6 response in
children 162.7 (144.0) vs 84. 8 (122.2) in adults; Wilcoxon sign
test, p=0.002). In contrast, there was no difference between TSPOT.
TB CFP-10 responses in adults and children (mean (SD)
response 29.9 (54.6) vs 24.9 (38.5), respectively). The magnitude
of the QTF ESAT-6 response was similar in children and adults
(mean (SD) response 4.0 (4.6) vs 1.1 (3.0); p=0.49); the mean
(SD) QTF CFP-10 response in children was 8.4 (14.4) compared
with 3.8 (7.6) in adults (p=0.61). Exploration of correlation
coefficients, although not significant, suggested an age-related
correlation between QTF and T-SPOT.TB CFP-10 responses
(adults r=0.71; children r=0.39; p=0.10 for comparison of
coefficients between groups) and a lesser correlation between
QTF and T-SPOT.TB ESAT-6 responses (adults r=0.34;
children r=20.06; p=0.14 for comparison of coefficients
between groups; figs 2 and 3).