Following an extensive review of the literature, there are a variety
of issues which are called into question in determining the best
staging and treatment for patients with ORN. There are a number
of different staging systems which have been published, but few
incorporate high resolution CT findings in determining the stage
of disease. Marx’s staging system is perhaps the most widely used
and is predicated on staging ORN based on response to treatment.1
Furthermore, there are few publications which address functional
outcomes after treatment for ORN (i.e. type of diet, ability to wear
dentures, resolution of trismus, and quality of life). Finally, most
studies have short durations of follow-up and hence do not address
the issue of disease progression over a patient’s lifetime.
In this review article, we will discuss the etiology, epidemiology,
and pathophysiology of ORN. Additionally, we will discuss
our current management strategies for ORN as well as strategies
to prevent the development of ORN.