The total synthesis of complex natu

The total synthesis of complex natural products has long
posed challenges to the top synthetic chemistry groups
worldwide and has led to dramatic advances in the field of
organic chemistry.139 In some instances, as noted in section
3.2 regarding the cytotoxic macrolide palmerolide A (13;
Scheme 3), total synthesis has led to a revision of the original
published structure;32 another notable example is that of the
marine-derived anti-tumor compound, diazonamide A