ApoE KOmiceanditswildtypemicewerefedatherogenicdietcontainingeither10%lard(LD)orperilla
oil (PE).InapoEKOgroupfedPE(APE),braintotalcholesterolandtrigrlycerideconcentrationswere
reducedby8and17%,respectively,thanapoEKOgroupfedLD(ALD).Brainlipidperoxidationand
NFkB expressionofAPEwereinhibitedby20.83and60%comparedtothosefortheALD.Neuronal
apoptosisofAPEwassignificantlyreducedby37%thanALDgroup.TheseresultssuggestthatPEwould
amelioratethebraindamageunderhypercholesterolemiainducedbyatherogenicdietviainhibiting
the oxidativestressandinflammation.