Extraction was carried out using various solvents,
namely water and ethanol, and also methanol in the
extraction of alkaloids and flavonoids compounds. The
use of water was intended to elucidate the toxicity and
the inhibition activity on xanthine oxidase of the
acquired extract, as water is usually used by the
society as solvent and boil their medicine. The
extraction with water was also compared to that of the
alcohol solvent, in this case is ethanol. Comparison
with the ethanol extraction is due to the fact that
ethanol is the best multipurpose solvent in the
preliminary extraction. The use of ethanol in the
preliminary extraction is focused on the reason that
ethanol has two functional groups with different
polarity; the hydroxyl group is polar while the alkyl
group is non-polar. Compounds with various polarity
levels are expected to be extracted in ethanol solvent
owing to the presence of these two functional groups in
ethanol.