currently individual vaccines vials and their component packaging vary significantly in overall lenght , width, and height. this is because the vaccine packaging size is determined by the dimension of both individual cylindrical vials and regtangular inner packs that typically of inner pack and vial dimension may hinder efficient vaccine distribution because it constrains packing of cold boxes and vaccinr carriers to quantities that are often inappropriate or suboptimal in the context of country-specific vaccination guideline. in particular, estimating storage space requirement is more difficult with nonstandard size and in a resource constrained system it may not be possible to take all the vaccine needed in a carrier because of the inefficient packaging.