Moreover, evidence is gathering that MSCs need an inflammatory
milieu to deliver immunosuppressive signals.
Next to bone marrow, adipose tissue also hosts multipotent stem cells.
These adipose-derived stem cells (ASCs) share multiple properties with
bone marrow-derived MSCs, but are more accessible and abundant
(5% vs 0.0001e0.001% of nucleated cells).
Both types have adipogenic,osteogenic and chondrogenic differentiation potential and display
immunosuppressive properties in vitro as well as in vivo.