The role of melatonin
Melatonin, the hormone secreted by the pineal gland, takes part in the regulation of sleep and circadian rhythm. Measurement of 6- sulfatoxymelatonin (6-SMT), which is a melatonin metabolite and is excreted with urine, reflects secretion of melatonin in healthy subjects.
The concentration of plasma melatonin though is more informative in critically ill patients with multi-organ failure.
Melatonin secretion is described suppressed in critically ill patients. Shilo et al. has studied day secretion of melatonin in a group of intensive care patients compared to a group of patients from ordinary medical wards.
He found a missing nocturnal top of melatonin in all intensive care patients but
two, and these did not require ventilator therapy.
Melatonin secretion was estimated from 6-SMT in urine samples, collected every third hour during 24 h.
The role of melatoninMelatonin, the hormone secreted by the pineal gland, takes part in the regulation of sleep and circadian rhythm. Measurement of 6- sulfatoxymelatonin (6-SMT), which is a melatonin metabolite and is excreted with urine, reflects secretion of melatonin in healthy subjects. The concentration of plasma melatonin though is more informative in critically ill patients with multi-organ failure.Melatonin secretion is described suppressed in critically ill patients. Shilo et al. has studied day secretion of melatonin in a group of intensive care patients compared to a group of patients from ordinary medical wards. He found a missing nocturnal top of melatonin in all intensive care patients buttwo, and these did not require ventilator therapy.Melatonin secretion was estimated from 6-SMT in urine samples, collected every third hour during 24 h.
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