at the G2/M phase. In addition, pac

at the G2/M phase. In addition, paclitaxel triggers apoptosis by
both caspase-dependent and caspase-independent pathways [2].
Because paclitaxel also inhibits division of normal cells, the major
limitation of paclitaxel is its extreme toxicity [3]. To overcome the
problem, it has been suggested that modulation of tumor-specific
signaling pathways may provide a different and complementary
approach to the clinical management of the disease [4]. In addition,
studies of combination chemotherapy have been focused on identifying
natural compounds that could increase the therapeutic index