The present study has clearly demonstrated that the deleterious clinical manifestations accompanying STZ-induced hyperglycemia in rat on a long term (12 weeks) high fat diet can be ameliorated by dietary riceberry supplement (up to
41%, w/w). These beneficial hypoglycemic, hypolipidemic, antioxidant, and anti-inflammation effects could be attributed
in part to the unique bioactive ingredients, rather than fiber content, present in riceberry bran. Although the results in the present study were obtained froma chemical-induced diabetes animal model, they are encouraging enough to warrant
evaluation in human subjects. There is also a need for further studies in order to clarify the specific roles of the bioactive constituents in ameliorating type 2 diabetes mellitus in humans