We included in this prospective stu

We included in this prospective study 98 consecutive patients with previous signs and symptoms suggestive for antibiotic-induced immediate-type hypersensitivity reactions ranging from urticaria, angioedema, and bronchospasm, to severe hypotension or cardiac arrest. The patients were referred to the allergy unit for testing by the general practitioners or anaesthesiologists as they required to undergo elective surgery under general anaesthesia. Each patient completed, guided by an allergologist, a structured questionnaire containing data regarding the date of the clinical reactions, the signs and symptoms, current medication and comorbidities. All patients presented positive skin tests for the culprit antibiotics (either the skin prick test or the intradermal test).