The mind and body interact in powerful ways that affect a person's health. The digestive system is profoundly controlled by the mind (brain), and anxiety, depression, and fear dramatically affect the function of this system (see Overview of the Digestive System). Social and psychologic stress can trigger or aggravate a wide variety of diseases and disorders, such as diabetes mellitus, high blood pressure, and migraine headache. However, the relative importance of psychologic factors varies widely among different people with the same disorder.