A meta-analysis of all randomized c

A meta-analysis of all randomized controlled trials evaluating interventions for depression in diabetes [including CBT, pharmacological, and collaborative (enhanced care) approaches] has recently been published [69]. The pooled results indicated that these interventions resulted in improvement of depressive symptom severity (moderate effect size, −0.512; 95% CI −0.633 to −0.390) and HbA1c (small effect size,
−0.274; 95% CI −0.402 to −0.147). The group concluded that the collaborative care trials were more representative of a general primary care population and that the more modest effect size on combined outcomes of depression and glycemic control (−0.292; 95% CI −0.429 to −0.155) would more likely reflect
clinical reality.