Although bisphosphonates are common

Although bisphosphonates are commonly used to treat
established HCM, they have also been given to prevent
the other SREs in patients with metastatic cancer to bone.
The bisphosphonates are nonhydrolyzable analogs of
inorganic pyrophosphate that adsorb to the surface of bone
hydroxyapatite and inhibit calcium release by interfering
with osteoclasts‑mediated bone resorption