As far as skin is concerned, numerous recent human clinical trials widely suggest that probiotic supplementation might be usefulIf live probiotic form appears to be essential for applications in which their metabolic properties are of importance,
some scientific groups showed that some semi-active or nonreplicating bacteria preparations retained activities comparable to the live forms (42,43). Such semi-active and non-replicating bacteria forms seemed to be of interest for topical
preparations designed for skin, beauty and health purposes in the management of atopic dermatitis and dry skin