1. Necessary Evaluation• History: Isolated bleeding symptoms consistent withthrombocytopenia without constitutional symptoms(e.g. significant weight loss, bone pain, night sweats).• Physical examination: Bleeding symptoms in the absenceof hepatosplenomegaly, lymphadenopathy, or stigmata ofcongenital conditions.• Complete blood count: Isolated thrombocytopenia (plateletcount <100 x 109/L). Anemia only if due to significantbleeding—otherwise normal red cell indices, white blood cellcount and differential.• Peripheral blood smear: Identified platelets should be normalto large in size. Red and white blood cell morphology shouldbe normal.2. Bone Marrow Evaluation• Bone marrow examination is unnecessary in patients withthe typical features of ITP outlined above, irrespective of theage of the patient.• Bone marrow examination is felt to be unnecessary inchildren with typical ITP prior to initiation of treatment withcorticosteroids, prior to splenectomy, or in patients who failintravenous immunoglobulin (IVIg) therapy.• The presence of abnormalities in the history, physicalexamination, or the complete blood count and peripheral bloodsmear should be further investigated, e.g. with a bone marrowexamination or other appropriate investigations, before thediagnosis of ITP is made.3. Additional Evaluations• All adult patients with newly diagnosed ITP should undergotesting for HIV and HCV.• There is insufficient evidence to support the routine use ofanti-platelet, antiphospholipid, and anti-nuclear antibodies,thrombopoietin levels, or platelet parameters obtained onautomated analyzers in the evaluation of patients withsuspected ITP.
การแปล กรุณารอสักครู่..
