[0055] The present inventors have

[0055] The present inventors have surprisingly found that a casein ไฮโดรไลเซต has a
beneficial effect on plasma concentration of อะดิโพเนคติน. Low อะดิโพเนคติน plasma levels are associated with type 1 diabetes, and increased weight.
[0056] It was also found that an ไฮโดรไลเซตที่มีเปปไทด์นมวัวที่ผ่านการไฮโดรไลซ์อย่างสูง had positive effects on the plasma concentration of อะดิโพเนคติน. Suitable
ไฮโดรไลเซตs casein ไฮโดรไลเซตs include casein ไฮโดรไลเซตs. It was furthermore found that
dialysis of the ไฮโดรไลเซต with a cut-off of 500 Da so as to include peptide sequences 500 Da and larger renders a ไฮโดรไลเซต fraction that has even better effect on the อะดิโพเนคติน plasma concentration. Accordingly, in particular embodiments, the ไฮโดรไลเซต ประกอบรวมด้วย peptides with a molecular weight of more than 500 Da, and in further embodiments, the ไฮโดรไลเซต
ประกอบรวมด้วย peptides with a molecular weight in a range of 500 to 2000 Da. In other
embodiments, the ไฮโดรไลเซต consists of peptides with a molecular weight of more than 500 Da, and in further embodiments, the ไฮโดรไลเซต consists of peptides with a molecular weight in a range of 500 to 2000 Da.
[0057] The following peptides have been identified as possibly contributing to the beneficial effect on อะดิโพเนคติน levels:
Table 1: identified peptide in the ไฮโดรไลเซต: