However, we found that the leptin level was not significantly
changed by capsaicin application. Leptin is the most important adipo-cytokine involved in the inter-organ cross-talk controlling weight ho-meostasis, insulin sensitivity, and many other key biological parame-ters, and it is highly expressed in adipocytes. Obesity is characterized
by elevated systemic levels of central and peripheral leptin resistance
(29). Serum leptin level is elevated during the development of obesity
and is decreased by diet-induced weight loss