Exposure of rat’s hind paw to hista

Exposure of rat’s hind paw to histamine resulted in a marked increase of paw tissue weight and skin thickness.
Paw weight significantly declined upon oral administration of AEBO (50 and 150 mg/kg) or loratadine (10 mg/ kg) at 60 min time point compared with the non-treated group (Figure 2). Moreover, the changes were also significant
for the dose of 150 mg/kg of AEBO compared to the non-treated group, from 180 min onwards. Although the paw volume reached its peak 60 min after histamine injection, the maximal edema inhibition was observed 300 min after the administration of 150 mg/kg of AEBO (76.0%). The percentages of inhibition produced by 150 mg/kg of AEBO at each time point (starting from 60 min) were 60.3%, 51.8%, 67.3%, 75.0% and 76.0%.