The BPH group showed a significant increase in serum DHT level (345 ± 8.17 pg/mL, P < 0.01) compared with the con- trol group (159 ± 8.34 pg/mL; Fig. 1). In contrast, the finasteride-treated group showed a significantly reduced serum DHT level (250.57 ± 25.68 pg/mL, P < 0.01) compared with the BPH group. Similarly to finasteride-treated group, the KH053-treated groups showed significant reduction in DHT levels (249.86 ± 35.07 pg/mL in the 200 mg/kg group, P < 0.05) compared with the BPH group.