Therefore, several studies have att

Therefore, several studies have attempted to explore the involvement of immediate-early genes in activity-dependent synaptic plasticity [23–25,31]. The activity-regulated cytoskeleton associated protein (Arc) is one of the immediate-early genes that have been implicated in the maintenance of long-term memory [9,21,25]. In several models of synaptic plasticity, e.g., stress [22], seizure [19], and long-term potentiation (LTP), Arc is rapidly activated and highly expressed in the brain [25]. Newly synthesized Arc mRNA is rapidly delivered into the active synaptic sites and then locally translated, suggesting that Arc plays a critical role in synaptic plasticity underlying the consolidation of long-term memory [28]. Although, many studies have investigated the molecular mechanisms of Arc expression [34,37], the exact mechanisms in activated neurons remain unrevealed.