The best multivariable model predic

The best multivariable model predicting CVM included age, established arterial disease, cystatin C and smoking (AICc value 77). Yes, the same thing All six multivariable models predicting CVM (AICc values ranging from 77 to 85) performed better than SCORE (AICc value 122). Stratification by steroid treatment did not influence the impact of cystatin C on mortality. Among those without history of nephritis (n = 135 of whom 25 died cystatin C adjusted for age remained significant; P = 0.009, RR 4.6 (95% CI 1.5 to 14.5). For patients with history of nephritis (n = 73 of whom 17 died), the results for cystatin C were similar; P = 0.001, RR 4.4 (95% CI 1.8 to 10.7). Results were comparable under the numerous imputed scenarios with the exception of cyclophosphamide, where a large proportion of missingness was observed among deceased patients, and alternative imputed scenarios yielded different results. As these were considered unreliable, they were removed from consideration.