Little is known about the efficacy

Little is known about the efficacy and safety of antipsychotic regimens for the treatment of many of the common anxiety disorders. Controlled evaluations in this area have been largely confined to treatment-resistant OCD, traumatic stress disorders, and generalized anxiety disorder. Findings from these evaluations have been largely favorable with regard to adjunctive antipsychotic treatment for OCD (27, 28) and promising but somewhat inconclusive with regard to antipsychotic treatment for traumatic stress disorders (29, 30). Findings from the small set of controlled evaluations of antipsychotic treatment for generalized anxiety or social anxiety disorders either have found no clinical benefit (31, 32) or often yielded inconsistent findings across outcomes (33, 34). In one promising, large controlled trial of generalized anxiety disorder (35), quetiapine demonstrated significant anxiety reductions relative to placebo, although with higher discontinuation rates relative to paroxetine as a result of adverse events. Controlled evaluations of antipsychotic treatment for panic disorder have not been conducted.