The incubation with microbial protease is one of methods to alleviate the adverse effect of antinutritional factors of soybean meal on the growth performance, nutrient assimilation and potential healthy problem of newly weaned pigs (Caine et al., 1997; 1998; Dierick et al., 2004; Song et al., 2010). Indeed, weaned pigs fed ESBM showed better growth performance and immune function in this study.