to form cationic trimethyl chitosan

to form cationic trimethyl chitosan. Secondly, the remaining amine groups of cationic trimethylchitosan were partially con-jugated with gluconolactone (GLU) to form the water soluble trimethyl-gluconate-chitosan. Finally, homo cysteine thiolactone was partially conjugated to introduce the thiol group and hence to enhance the mucoadhesive property.