After cooling the emulsion droplets crystallize forming lipid
nanoparticles with solid particle matrix, depending on the starting material either SLN
or NLC. The advantage of the second generation technology is the increased loading
with actives compared to SLN and firmer inclusion of the active inside the particle
matrix during the shelf life. By preparing the particles from a solid lipid, especially
highly purified solid lipids, the particle matrix tends to form a relatively perfect crystal
lattice leaving limited space to accommodate the active.