Although salvage regimens used in treatmentexperienced
patients are in general much less successful
at controlling viraemia than primary regimens,10,11 the
proportion of patients achieving viral suppression in
this trial was fairly low. Molina and colleagues suggest
the low overall effi cacy is attributable to the high
proportion of voluntary discontinuations: these are
counted as failures in the modifi ed intention-to-treat
analysis. They argue that this level of discontinuation
refl ects a behavioural change in treatment-experienced
patients infected with HIV; with more treatment
options available nowadays, motivation to adhere to a
certain regimen wanes.