Originally, I started taking Pycnogenol to ameliorate the symptoms of von Willebrand disease (a blood coagulation disorder), and it certainly helped reduce the frequency of nosebleeds. Beyond that, however, I noticed that my usually cool hands and feet were warm and flushed with color, even in cold environments. After about two weeks, I noticed that my skin was clearer, more even, and more smooth than it has ever been before. If my results are typical, this brand's (Healthy Origins) Pycnogenol is high-quality and also a very good value. I've recommended it to those dealing with blood coagulation/clotting disorders, to those with high blood pressure, as well as to those with erectile dysfunction. Healthy Origins, Pycnogenol truly deserves five (out of five possible) stars.