2.3. Statistical analysis
The distribution of all of the tested SNPs did not deviate significantly
fromthe Hardy–Weinberg Equilibrium(HWE) (p N 0.05) except for NgR
rs701428, (p = 2.34 × 10−13) which was then excluded from further
analysis. To detect associations between each SNP and schizophrenia,
chi-square (χ2) analysis was performed to test for significant differences
in allele and genotype frequencies between the case and control
groups. The significance for all statistical tests was set to p b 0.05. Data
are expressed as specific counts for alleles and genotypes. Bonferroni
correction was utilized to adjust for multiple comparisons in the SNP
analysis resulting in a corrected significance level of p b 0.004 to give a
95% probability of correctly concluding not to reject the null hypothesis
in the χ2 test.