When disease does strike older adults, the effects can be more debilitating than in younger adults. In addition, presentation may be different (for example, sepsis may not be accompanied by fever), so it’s important to anticipate subtle signs and symptoms. Finally, the care of older adults requires knowledge of both physiologic and psychosocial phenomena; the loss of independence that results from physical decline can have adverse psychological consequences, such as depression, and social isolation can accompany role changes such as those brought about by retirement or widowhood. The American Psychiatric Association notes that adults over 65 have the highest suicide rate in the country. (For more information go to www.psych.org/public_ info/elderly.cfm.) Appropriate support can facilitate a more positive response to these changes.